Sarras M P
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City 66160-7400, USA.
Bioessays. 1996 Jun;18(6):439-42. doi: 10.1002/bies.950180604.
Members of the astacin family of metalloproteinases such as human bone morphogenetic protein 1 (BMP-1) have previously been linked to cell differentiation and pattern formation during development through a proposed role in the activation of latent growth factors of the TGF-beta superfamily. Recent findings indicate that BMP-1 is identical to pro-collagen C-proteinase, which is a metalloproteinase involved in extracellular matrix (ECM) formation. This observation suggests that a functional link may exist between astacin metalloproteinases, growth factors and cell differentiation and pattern formation during development. Taken together, current studies indicate that BMP-1 and possibly other astacin metalloproteinases are multifunctional enzymes that act directly on growth factors and the ECM. In combination, these dual actions would have profound effects on developmental processes.
金属蛋白酶虾红素家族的成员，如人类骨形态发生蛋白1（BMP - 1），此前已通过在转化生长因子 - β超家族潜在生长因子激活中的假定作用，与发育过程中的细胞分化和模式形成联系起来。最近的研究结果表明，BMP - 1与前胶原C蛋白酶相同，前胶原C蛋白酶是一种参与细胞外基质（ECM）形成的金属蛋白酶。这一观察结果表明，虾红素金属蛋白酶、生长因子以及发育过程中的细胞分化和模式形成之间可能存在功能联系。综上所述，目前的研究表明，BMP - 1以及可能的其他虾红素金属蛋白酶是直接作用于生长因子和细胞外基质的多功能酶。这些双重作用结合起来，将对发育过程产生深远影响。
