B细胞发育中的替代轻链 - Suppr

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Surrogate light chain in B cell development.

作者信息

Karasuyama H, Rolink A, Melchers F

机构信息

Department of Immunology, The Tokyo Metropolitan Institute of Medical Science, Japan.

出版信息

Adv Immunol. 1996;63:1-41. doi: 10.1016/s0065-2776(08)60853-6.

DOI:10.1016/s0065-2776(08)60853-6

PMID:8787628

Abstract

摘要

相似文献

Surrogate light chain in B cell development.B细胞发育中的替代轻链

Adv Immunol. 1996;63:1-41. doi: 10.1016/s0065-2776(08)60853-6.

Surrogate light chain production during B cell differentiation: differential intracellular versus cell surface expression.B细胞分化过程中的替代轻链产生：细胞内与细胞表面表达的差异

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Surrogate-light-chain silencing is not critical for the limitation of pre-B cell expansion but is for the termination of constitutive signaling.替代轻链沉默对于前B细胞扩增的限制并非至关重要，但对于组成性信号传导的终止却是至关重要的。

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Normal pre-B cells express a receptor complex of mu heavy chains and surrogate light-chain proteins.正常前B细胞表达μ重链和替代轻链蛋白的受体复合物。

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A complex of glycoproteins is associated with VpreB/lambda 5 surrogate light chain on the surface of mu heavy chain-negative early precursor B cell lines.一种糖蛋白复合物与μ重链阴性早期前体B细胞系表面的VpreB/λ5替代轻链相关联。

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The transient expression of pre-B cell receptors governs B cell development.前B细胞受体的瞬时表达控制着B细胞的发育。

Semin Immunol. 2002 Oct;14(5):343-9. doi: 10.1016/s1044-5323(02)00067-2.

A truncated heavy chain protein relieves the requirement for surrogate light chains in early B cell development.一种截短的重链蛋白可缓解早期B细胞发育中对替代轻链的需求。

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Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development.在早期B细胞发育过程中，需要替代轻链表达来建立免疫球蛋白重链等位基因排斥。

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