来自马胃葡萄球菌的大环内酯-林可酰胺-链阳菌素B耐药质粒pSES6的ermC翻译衰减子中的串联重复。
Tandem duplication in ermC translational attenuator of the macrolide-lincosamide-streptogramin B resistance plasmid pSES6 from Staphylococcus equorum.
作者信息
Lodder G, Schwarz S, Gregory P, Dyke K
机构信息
Institut für Kleintierforschung Celle/Merbitz, Bundesforschungsanstalt für Landwirtschaft Braunschweig-Völkenrode, Celle, Germany.
出版信息
Antimicrob Agents Chemother. 1996 Jan;40(1):215-7. doi: 10.1128/AAC.40.1.215.
Abstract
A tandem duplication of 23 bp in the ermC gene translational attenuator of plasmid pSES6 from Staphylococcus equorum which mediated constitutive resistance to macrolide-lincosamide-streptogramin B antibiotics was identified. This duplication included the ribosome binding site for the ermC gene as well as the first 5 bp of the ermC coding sequence. It was postulated that this sequence duplication affects the possible RNA conformations so that the ribosome binding site for ErmC synthesis is readily accessible to the ribosomes and thus constitutive expression of the ermC gene occurs.
摘要
在马胃葡萄球菌质粒pSES6的ermC基因翻译弱化子中发现了一个23 bp的串联重复，该重复介导了对大环内酯-林可酰胺-链阳菌素B类抗生素的组成型抗性。这种重复包括ermC基因的核糖体结合位点以及ermC编码序列的前5 bp。据推测，这种序列重复影响了可能的RNA构象，使得用于ErmC合成的核糖体结合位点易于被核糖体接近，从而发生ermC基因的组成型表达。
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