迟缓葡萄球菌对大环内酯-林可酰胺-链阳菌素B的耐药性是由转座子的一部分整合到一个小质粒中所致。
Macrolide-lincosamide-streptogramin B resistance in Staphylococcus lentus results from the integration of part of a transposon into a small plasmid.
作者信息
Werckenthin C, Schwarz S, Dyke K
机构信息
Institut für Kleintierforschung Celle/Merbitz, Bundesforschungsansalt für Landwirtschaft Braunschweig-Völkenrode (FAL), Celle, Germany.
出版信息
Antimicrob Agents Chemother. 1996 Sep;40(9):2224-5. doi: 10.1128/AAC.40.9.2224.
Abstract
The 8.0-kb macrolide-lincosamide-streptogramin B resistance plasmid pSES20 from Staphylococcus lentus harbored part of a Tn917-like transposon including the left terminal repeat, a gene almost identical to ermB, and its regulatory region, as well as the internal direct repeat. Homology between pSES20 and Tn917 ended at a sequence closely related to those of the resolution sites of Tn917 and Tn552 and staphylococcal recombination sites.
摘要
来自迟缓葡萄球菌的8.0 kb大环内酯-林可酰胺-链阳霉素B耐药质粒pSES20含有一部分Tn917样转座子，包括左末端重复序列、一个与ermB几乎相同的基因及其调控区，以及内部正向重复序列。pSES20与Tn917之间的同源性在一个与Tn917和Tn552的解离位点以及葡萄球菌重组位点的序列密切相关的序列处终止。
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