Knapp M, Durner M, Baur M P
Institute for Medical Statistics, University of Bonn, Germany.
Genet Epidemiol. 1995;12(6):619-23. doi: 10.1002/gepi.1370120616.
We applied linkage analysis with a sib-pair method, which also takes into account information on unaffected siblings, and family-based methods of association analysis to determine the disease affecting loci in Problem 1. Whereas the first two disease loci were correctly identified by association analysis, the sib-pair linkage method failed to detect the disease loci 3 and 4. We therefore determined the data structure and sample size necessary for demonstrating linkage to these loci.
