Matise T C
Department of Psychiatry, Columbia University, New York, NY 10032, USA.
Genet Epidemiol. 1995;12(6):641-5. doi: 10.1002/gepi.1370120620.
Two tests for allelic association were applied to a simulated complex disease for the Genetic Analysis Workshop 9. The transmission/disequilibrium test [Spielman et al., 1993] and the haplotype-based haplotype relative risk approach [Terwilliger and Ott, 1992] were used to detect disease-associated alleles in a set of 360 computer-simulated markers located on six chromosomes and genotyped in 200 nuclear families. This analysis emulates a genome-based search for linked markers. Computer simulations were also performed to clarify statistical properties of the TDT.
针对遗传分析研讨会9的模拟复杂疾病，应用了两种等位基因关联测试。采用传递/不平衡测试[斯皮尔曼等人，1993年]和基于单倍型的单倍型相对风险方法[特威利格和奥特，1992年]，在位于6条染色体上的360个计算机模拟标记集中检测疾病相关等位基因，并对200个核心家庭进行基因分型。该分析模拟了基于基因组的连锁标记搜索。还进行了计算机模拟以阐明传递/不平衡测试的统计特性。
