使用配子不平衡方法对易感基因座进行系统搜索。

Systematic search of susceptibility loci with methods using gametic disequilibrium.

作者信息

Bickeböller H, Margaritte-Jeannin P, Babron M C, Clerget-Darpoux F

机构信息

INSERM U155, Paris, France.

出版信息

Genet Epidemiol. 1995;12(6):577-82. doi: 10.1002/gepi.1370120609.

DOI:10.1002/gepi.1370120609

PMID:8787976

Abstract

Susceptibility genes are identified for a simulated complex trait by a systematic genome search for linkage between disease and a genetic marker in the presence of gametic disequilibrium. The transmission/disequilibrium tests TDTa or TDTg for multiallelic markers compare transmitted and nontransmitted alleles or the genotypes formed by the two transmitted alleles and the genotypes formed by the two nontransmitted alleles, respectively. With these two tests we were able to identify the two markers D1G31 and D5G23. Under the simulating model these are in fact two susceptibility genes involved in the disease.

摘要

在配子不平衡存在的情况下，通过对疾病与遗传标记之间的连锁进行系统的基因组搜索，为模拟的复杂性状鉴定易感基因。针对多等位基因标记的传递/不平衡检验TDTa或TDTg分别比较传递和未传递的等位基因，或由两个传递等位基因形成的基因型与由两个未传递等位基因形成的基因型。通过这两种检验，我们能够鉴定出两个标记D1G31和D5G23。在模拟模型下，实际上这是两个与该疾病相关的易感基因。