Rice J P, Neuman R J, Hoshaw S L, Daw E W, Gu C
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Genet Epidemiol. 1995;12(6):659-64. doi: 10.1002/gepi.1370120623.
We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the population prevalence or penetrances of a single locus.
我们描述了对TDT（传递/不平衡检验）的一种扩展，它允许存在两个以上的标记等位基因，并且可以对亲本或子代测量协变量。我们还描述了一种系统的基因组搜索方法，即在单个位点的群体患病率或外显率的约束条件下，为每个标记计算mod得分（最大对数优势得分）。
