带有协变量的传递不平衡检验以及具有修正分数的基因组筛选：它们在模拟数据上的表现。
TDT with covariates and genomic screens with mod scores: their behavior on simulated data.
作者信息
Rice J P, Neuman R J, Hoshaw S L, Daw E W, Gu C
机构信息
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
出版信息
Genet Epidemiol. 1995;12(6):659-64. doi: 10.1002/gepi.1370120623.
PMID:8787990
Abstract
We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the population prevalence or penetrances of a single locus.
摘要
我们描述了对TDT（传递/不平衡检验）的一种扩展，它允许存在两个以上的标记等位基因，并且可以对亲本或子代测量协变量。我们还描述了一种系统的基因组搜索方法，即在单个位点的群体患病率或外显率的约束条件下，为每个标记计算mod得分（最大对数优势得分）。
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