Herremans A H, Hijzen T H, Olivier B, Slangen J L
Department of Psychopharmacology, Utrecht University, Netherlands.
J Neurosci Methods. 1995 Dec;63(1-2):29-35. doi: 10.1016/0165-0270(95)00082-8.
The present study investigated whether changes in response bias (log b) affect discriminability (log d) in a delayed conditional discrimination (DCD) task. Eight rats were trained on an DCD task and response bias was manipulated by changing the reinforcement ratio (RR) for correct responding on the two response alternatives. Three findings emerged. First, changes in RR produced changes in log b and the magnitude of these changes was related to the value of the RR. Second, log d was affected by changing RRs. Third, the effect of changes in RR on log b was larger after longer delays. These results suggest that log d and log b are not independent and it is concluded that changes in response bias (log b) may affect the discriminability measure log d. This implies that changes in log d may be mediated by changes in response bias and it is therefore recommended that log d and log b values are both reported when investigating effects of, for example, pharmacological manipulations on DCD performance.
本研究调查了在延迟条件辨别（DCD）任务中，反应偏差（log b）的变化是否会影响辨别力（log d）。八只大鼠接受了DCD任务训练，并通过改变两种反应选择上正确反应的强化比率（RR）来操纵反应偏差。出现了三个结果。首先，RR的变化导致log b发生变化，且这些变化的幅度与RR的值相关。其次，log d受RR变化的影响。第三，延迟时间越长，RR变化对log b的影响越大。这些结果表明log d和log b并非相互独立，得出的结论是反应偏差（log b）的变化可能会影响辨别力指标log d。这意味着log d的变化可能由反应偏差的变化介导，因此建议在研究例如药物操作对DCD表现的影响时，同时报告log d和log b的值。
