Romero B, Kurz A
Technische Universität München, Deutschland.
Dementia. 1996 Jan-Feb;7(1):35-40. doi: 10.1159/000106850.
This longitudinal study measured the rate of spontaneous speech decline in patients with Alzheimer's disease (AD) at a 1-year follow-up and determined the effect of clinical and demographic factors on that rate. In addition the pattern of spontaneous speech impairment was examined. The expected pattern of spontaneous speech impairment with prominent disturbances of communication and semantics, moderate disturbances of automatic speech, but with retained phonematic structures, was found at baseline and at follow-up in the majority of our rather large sample (n = 63). This result is discussed in terms of intrafunctional homogeneity and of selective involvement of neuronal systems in AD. There was a trend for a more rapid language decline in patients with a family history of dementia. No relationship was detected between the rate of spontaneous speech decline and other clinical and demographic factors, with the exception of initial spontaneous speech impairment.
这项纵向研究在1年的随访中测量了阿尔茨海默病（AD）患者自发言语下降的速率，并确定了临床和人口统计学因素对该速率的影响。此外，还检查了自发言语障碍的模式。在我们相当大的样本（n = 63）中的大多数患者的基线和随访中，发现了预期的自发言语障碍模式，即存在明显的交流和语义障碍、中度的自动言语障碍，但语音结构保留。根据功能内同质性以及AD中神经元系统的选择性受累对这一结果进行了讨论。有痴呆家族史的患者存在语言下降更快的趋势。除了初始自发言语障碍外，未发现自发言语下降速率与其他临床和人口统计学因素之间存在关联。
