McKinnon B T
Department of Clinical Pharmacy, University of Tennessee, Memphis, USA.
Nutr Clin Pract. 1996 Apr;11(2):59-65. doi: 10.1177/011542659601100259.
In April 1994, the Food and Drug Administration issued a Safety Alert regarding the hazards of precipitation associated with parenteral nutrition in response to reports of two deaths and at least two cases of respiratory distress in patients receiving three-in-one admixtures. The admixtures were thought to contain a precipitate of calcium phosphate, and patient autopsies revealed diffuse microvascular pulmonary emboli. The American Society for Parenteral and Enteral Nutrition took an active role in informing its members of the alert and responding to their concerns. Release of the alert has caused nutrition practitioners to reevaluate their compounding practices, use of filters, prescribing practices for calcium and phosphate in parenteral nutrition solutions, and use of three-in-one admixtures.
1994年4月，美国食品药品监督管理局发布了一份关于肠外营养相关沉淀危害的安全警报，以回应两例死亡报告以及至少两例接受三合一混合液治疗的患者出现呼吸窘迫的病例。据认为，这些混合液中含有磷酸钙沉淀，患者尸检显示肺部有弥漫性微血管栓塞。美国肠外和肠内营养学会积极向其成员通报该警报，并回应他们的关切。该警报的发布促使营养从业者重新评估他们的配液操作、过滤器的使用、肠外营养溶液中钙和磷的处方做法以及三合一混合液的使用。
