Lovallo W R, al'Absi M, Pincomb G A, Everson S A, Sung B H, Passey R B, Wilson M F
Veterans Affairs Medical Center and University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA.
Health Psychol. 1996 Jan;15(1):11-17. doi: 10.1037//0278-6133.15.1.11.
Caffeine in dietary amounts raises blood pressure (BP), and its use increases during work stress; however, caffeine combined with behavioral stress has not been tested in borderline hypertensive (BH) men. Accordingly, this study tested a psychomotor stressor plus caffeine (3.3 mg/kg, equivalent to 2-3 cups of coffee) using a double-blind, crossover design in 24 BH men (140/90 mmHg < or = BP < or = 160/95 mmHg) and 24 controls (BP < or = 135/85 mmHg). BH men had modestly larger BP increases to the task and showed a greater combined effect of caffeine plus the task (+15/+11 mmHg) than controls (+10/+6 mmHg). BH men maintained response to the stressor in the face of an exaggerated BP response to caffeine, suggesting that use of caffeine during behavioral stress may elevate BP in BH individuals to a clinically meaningful degree.
饮食中适量的咖啡因会升高血压（BP），且在工作压力期间其摄入量会增加；然而，咖啡因与行为应激相结合对临界高血压（BH）男性的影响尚未得到测试。因此，本研究采用双盲、交叉设计，对24名BH男性（血压为140/90 mmHg≤BP≤160/95 mmHg）和24名对照组男性（BP≤135/85 mmHg）进行了一项心理运动应激源加咖啡因（3.3毫克/千克，相当于2至3杯咖啡）的测试。BH男性对该任务的血压升高幅度略大，且与对照组（+10/+6 mmHg）相比，咖啡因加任务的联合效应更大（+15/+11 mmHg）。尽管对咖啡因的血压反应过度，但BH男性对该应激源仍保持反应，这表明在行为应激期间使用咖啡因可能会使BH个体的血压升高到具有临床意义的程度。
