Prisco D, Paniccia R, Francalanci I, Bandinelli B, Filippini M, Bacci F, Rostagno C, Abbate R, Gensini G F
Istituto di Clinica Medica Generale e Cardiologia, Università Degli Studi di Firenze, Florence, Italy.
Int J Clin Lab Res. 1995;25(4):222-5. doi: 10.1007/BF02592702.
Fibrin generation and lysis were studied in 28 patients with angina pectoris (14 with active disease and 14 with inactive disease) and in 14 normal controls. The fibrinolytic response was evaluated by comparing the ratio between the plasma levels of fibrinopeptide A and fibrin degradation products. Levels of both were higher in patients than in controls (P < 0.001), with higher levels in active than in inactive disease (P < 0.001). The fibrinopeptide A/fibrin degradation products ratio was much higher (P < 0.001) in the active group than in other groups. Thus, in patients with angina pectoris, especially in the active state, the increased thrombin generation is not paralleled by an equivalent increase in fibrinolytic activity.
对28例心绞痛患者（14例为活动期疾病患者，14例为非活动期疾病患者）和14名正常对照者进行了纤维蛋白生成和溶解的研究。通过比较纤维蛋白肽A和纤维蛋白降解产物的血浆水平之间的比率来评估纤维蛋白溶解反应。患者体内两者的水平均高于对照者（P<0.001），活动期疾病患者的水平高于非活动期疾病患者（P<0.001）。活动组的纤维蛋白肽A/纤维蛋白降解产物比率比其他组高得多（P<0.001）。因此，在心绞痛患者中，尤其是在活动期，凝血酶生成增加，但纤维蛋白溶解活性并未相应增加。
