Giess R, Schlote W
Neuropathologisches Institut, J.W. Goethe Universität, Frankfurt am Main, Germany.
Mech Ageing Dev. 1995 Oct 27;84(3):209-26. doi: 10.1016/0047-6374(95)01657-0.
The brainstems of ten patients with Alzheimer's disease were examined with specific silver impregnations for beta-amyloid deposits, neurofibrillary tangles, neuropil threads and neuritic plaques. The results show a selective and focal involvement of brainstem nuclei, which are diffusely connected to the cortex or are neuronally connected with other damaged subcortical and cortical regions. Therefore, it is concluded that neuronal connectivity plays an important role in the pathogenesis of Alzheimer's disease lesions. This may be due to the intraneuronal transport of beta-amyloid precursor protein. There was a local association between neurofibrillary tangles and neuropil threads, but not between beta-amyloid structures on the one hand and neurofibrillary structures on the other hand. Neuritic plaques were rarely found.
对10例阿尔茨海默病患者的脑干进行了检查，采用特异性银浸染法检测β-淀粉样蛋白沉积、神经原纤维缠结、神经毡丝和神经炎性斑块。结果显示脑干核团存在选择性和局灶性受累，这些核团与皮质广泛相连，或与其他受损的皮质下和皮质区域存在神经元连接。因此，得出结论，神经元连接在阿尔茨海默病病变的发病机制中起重要作用。这可能是由于β-淀粉样前体蛋白的神经元内运输所致。神经原纤维缠结与神经毡丝之间存在局部关联，但β-淀粉样结构与神经原纤维结构之间不存在关联。神经炎性斑块很少见。
