Ohm T G, Braak H
J.W. Goethe-Universität, Zentrum d. Morphologie, Frankfurt, F.R.G.
Neurosci Lett. 1989 Jan 2;96(1):60-3. doi: 10.1016/0304-3940(89)90243-7.
Serial sections of 7 Alzheimer brainstems were examined. The histopathological hallmarks were demonstrated by means of Kongo red- and silver-stained preparations. A subsequent counterstaining with a Nissl dye, allowing the cytoarchitectonical interpretation, revealed a considerable plaque formation in the central nucleus and the dorsomedial nucleus of the inferior colliculus. To a lesser degree plaques were also present in the deep layers of the dorsal cortex of the inferior colliculus. All other auditory brainstem nuclei were devoid of neuritic plaques. Neurofibrillary tangles were rarely seen. They occur in the dorsal cochlear nucleus, the periolivary region, the ventral nucleus of the lateral lemniscus, and in the central nucleus of the inferior colliculus.
对7个阿尔茨海默病患者的脑干连续切片进行了检查。通过刚果红染色和银染色制剂展示了组织病理学特征。随后用尼氏染料进行复染，以便进行细胞结构解释，结果显示在下丘中央核和背内侧核中有大量斑块形成。在下丘背侧皮质深层也有程度较轻的斑块。所有其他听觉脑干核均无神经炎性斑块。神经原纤维缠结很少见。它们出现在蜗背侧核、橄榄周区域、外侧丘系腹侧核以及下丘中央核中。
