King D, Cheever L W, Hood A, Horn T D, Rinaldi M G, Merz W G
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-7093.
J Clin Microbiol. 1996 Feb;34(2):460-2. doi: 10.1128/jcm.34.2.460-462.1996.
Two cases of primary invasive cutaneous infections caused by the zoophilic dermatophytic species Microsporum canis are presented. The first case occurred in a liver transplant recipient who was receiving immunosuppressive therapy. Multiple erythematous papules were seen on both legs, and a biopsy revealed invasive fungal hyphae. The second case was diagnosed in a human immunodeficiency virus-positive individual with a CD4 lymphocyte count of 81 mm3. Raised red nodules were seen on her scalp and face. Histopathology was consistent with bacillary angiomatosis, and in addition, invasive septate hyphae were observed. The two strains recovered from the biopsy specimens from both individuals had colony morphologies consistent with that of M. canis, but it was difficult to induce production of macroconidia. These cases serve to increase the awareness of this unusual infection, reinforce the need for cultures, and raise some interesting questions about the potential virulence of this dermatophyte species.
本文报告了两例由亲动物性皮肤癣菌犬小孢子菌引起的原发性侵袭性皮肤感染病例。第一例发生在一名接受免疫抑制治疗的肝移植受者身上。其双下肢可见多个红斑丘疹，活检显示有侵袭性真菌菌丝。第二例诊断为一名CD4淋巴细胞计数为81/mm³的人类免疫缺陷病毒阳性个体。她的头皮和面部可见隆起的红色结节。组织病理学与杆菌性血管瘤病一致，此外，还观察到侵袭性有隔菌丝。从这两名患者活检标本中分离出的两株菌株，其菌落形态与犬小孢子菌一致，但难以诱导产生大分生孢子。这些病例有助于提高对这种不寻常感染的认识，强化培养的必要性，并引发了一些关于这种皮肤癣菌潜在毒力的有趣问题。
