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犬小孢子菌在免疫抑制患者中引起的地图状红斑性损害。

Figurate erythematous lesion by Microsporum canis in immunosuppressed patient.

作者信息

Botelho Karine Paschoal, Soares Yuri Coelho, Gonçalves Deborah Pereira, Melo Bárbara Lima Araújo

机构信息

Outpatient Department of General Dermatology, Centro de Dermatologia Dona Libânia - Fortaleza (CE), Brazil.

Department of Rheumatology, Hospital Universitário Walter Cantídio - Universidade Federal do Ceará (HUWC-UFC) - Fortaleza (CE), Brazil.

出版信息

An Bras Dermatol. 2018 Jan-Feb;93(1):141-142. doi: 10.1590/abd1806-4841.20187094.

DOI:10.1590/abd1806-4841.20187094
PMID:29641719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5871384/
Abstract

Dermatophytes are fungi capable of invading keratinized tissues. Isolation of the fungus with the culture is essential to guide the treatment, because there are more resistant species like Microsporum canis. The chronic use of corticosteroids leads to the deregulation of immunity, promoting atypical manifestations of infections. Topical antifungal therapy is often insufficient, requiring systemic medications. We describe the case of a patient undergoing systemic corticosteroid therapy with a large figurate lesion who presented complete response to exclusively topical treatment.

摘要

皮肤癣菌是能够侵犯角化组织的真菌。通过培养分离真菌对于指导治疗至关重要,因为存在像犬小孢子菌这样更具耐药性的菌种。长期使用皮质类固醇会导致免疫失调,促进感染的非典型表现。局部抗真菌治疗往往不足,需要全身用药。我们描述了一例接受全身皮质类固醇治疗且有大片地图状损害的患者,该患者仅接受局部治疗就获得了完全缓解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65cd/5871384/8aa0e15f0fe4/abd-93-01-0141-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65cd/5871384/4d61d5569b0b/abd-93-01-0141-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65cd/5871384/cda048f9dc32/abd-93-01-0141-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65cd/5871384/835bc9ed528b/abd-93-01-0141-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65cd/5871384/8aa0e15f0fe4/abd-93-01-0141-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65cd/5871384/4d61d5569b0b/abd-93-01-0141-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65cd/5871384/cda048f9dc32/abd-93-01-0141-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65cd/5871384/835bc9ed528b/abd-93-01-0141-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65cd/5871384/8aa0e15f0fe4/abd-93-01-0141-g04.jpg

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本文引用的文献

1
Dermatophytosis caused by Tricophyton rubrum as an opportunistic infection in patients with Cushing disease.
An Bras Dermatol. 2010 Nov-Dec;85(6):888-90. doi: 10.1590/s0365-05962010000600017.
2
Evaluation and management of fungal infections in immunocompromised patients.免疫功能低下患者真菌感染的评估与管理
Dermatol Ther. 2005 Jan-Feb;18(1):44-57. doi: 10.1111/j.1529-8019.2005.05001.x.
3
Glucocorticoids and invasive fungal infections.糖皮质激素与侵袭性真菌感染。
Lancet. 2003 Nov 29;362(9398):1828-38. doi: 10.1016/S0140-6736(03)14904-5.
4
Primary invasive cutaneous Microsporum canis infections in immunocompromised patients.免疫功能低下患者的原发性侵袭性皮肤犬小孢子菌感染
J Clin Microbiol. 1996 Feb;34(2):460-2. doi: 10.1128/jcm.34.2.460-462.1996.
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Dermatophytes as opportunistic pathogens.皮肤癣菌作为机会性致病菌。
J Am Acad Dermatol. 1994 Jun;30(6):1021-2. doi: 10.1016/s0190-9622(09)80146-1.