Gormsen J, Nielsen J D, Dalsgaard J, Andersen L A
Acta Med Scand. 1977;201(6):509-13. doi: 10.1111/j.0954-6820.1977.tb15738.x.
ADP-induced platelet aggregation in vitro has been studied in 90 normal controls and in 30 patients with ischemic heart disease (IHD) and 22 with peripheral thromboatherosclerosis (PTA). The sensitivity to ADP was defined by the threshold concentration which produced secondary aggregation with an amplitude corresponding to not less than 80% of the transmission obtained by platelet-poor plasma. In the normal controls the threshold concentration was significantly lower in women aged 50 or more than in women under that age. The geometric means were lower in the patients than in the controls. Significantly lower threshold concentrations than in the corresponding age groups of controls were found in the following age groups of patients: Men and women greater than or equal to 50 years with IHD (p less than 0.005 and p less than 0.001, respectively), men and women under 50 with IHD (p less than 0.05). Men and women greater than or equal to 50 years with PTA (p less than 0.002 and p less than 0.01, respectively), men and women under 50 with PTA (p less than 0.005).
已对90名正常对照者、30例缺血性心脏病（IHD）患者和22例周围血栓性动脉粥样硬化（PTA）患者进行了体外ADP诱导的血小板聚集研究。对ADP的敏感性由阈值浓度定义，该阈值浓度产生的二次聚集幅度相当于由贫血小板血浆获得的透光度的不少于80%。在正常对照者中，50岁及以上女性的阈值浓度显著低于该年龄以下的女性。患者的几何平均值低于对照者。在以下患者年龄组中发现阈值浓度显著低于相应年龄组的对照者：年龄大于或等于50岁的IHD男性和女性（分别为p<0.005和p<0.001），年龄小于50岁的IHD男性和女性（p<0.05）。年龄大于或等于50岁的PTA男性和女性（分别为p<0.002和p<0.01），年龄小于50岁的PTA男性和女性（p<0.005）。
