Nováková V, Sterc J, Mozes S
Institute of Animal Physiology, Slovak Academy of Sciences, Kosice.
Physiol Res. 1995;44(2):105-111.
Bilateral lesions of the dorsal part of the septal area were produced in the brain of female rats of Wistar and Long-Evans stocks. The cytogram of their vaginal smears was evaluated repeatedly from the 30th day after surgery and permanent impairment of their oestrous cycle was found. In comparison with intact control females, oestrous phases were detected more frequently whereas dioestrous phases were observed less frequently. The proportions between the individual periods of the oestrous phase (i.e. pro-oestrus, oestrus and metoestrus) were equal in both septal and intact animals. No difference was found between the rat stocks used. Similarly, the previous life history of the rats which had been housed either in a socially impoverished environment (i.e. single cages) or in large communities (colonies) exerted no influence upon the postoperative impairment of the oestrous cycle.
在Wistar和Long-Evans品系的雌性大鼠脑内制造了隔区背侧的双侧损伤。从手术后第30天起反复评估其阴道涂片的细胞图谱，发现其发情周期出现永久性损害。与完整的对照雌性大鼠相比，发情期被检测到的频率更高，而间情期被观察到的频率更低。发情期各个阶段（即动情前期、发情期和动情后期）之间的比例在隔区损伤的动物和完整动物中是相等的。所用的大鼠品系之间未发现差异。同样，之前饲养在社会隔离环境（即单笼饲养）或大群体（群落）中的大鼠的生活史，对术后发情周期的损害也没有影响。
