INRA, UR1197 Neurobiologie de l'Olfaction et Modélisation en Imagerie, F-78352 Jouy-en-Josas, France.
Behav Brain Res. 2011 Dec 1;225(2):584-9. doi: 10.1016/j.bbr.2011.08.026. Epub 2011 Aug 22.
A common set of odorous molecules may indicate female receptiveness across species, as male rats display sexual arousal when exposed to the odour of oestrous faeces from rats, vixens and mares. More than 900 different compounds were identified by GC-MS analyses performed on faeces samples from di-oestrous and oestrous females and from males of the three species. Five carboxylic acids were found in lower concentrations in faeces from all oestrous females. We subjected 12 sexually trained male rats to a 30 min exposure to different dilutions of a mixture of these five molecules in the same proportions as found in female oestrous faeces. The behavioural responses of the rats were compared to those displayed when exposed to water (negative control) and faeces from oestrous female rats (positive control). Frequency of penile erections were found to be significantly dependent on mixture dilution, with two intermediate dilutions eliciting frequencies of penile erections that did not differ from those obtained during exposure to oestrous female rat faeces. Higher and lower dilutions did not elicit more penile erections than observed with water. These results support our hypothesis that a small set of odorous molecules may indicate sexual receptiveness in mammalian females.
一组常见的有气味的分子可能在不同物种中表明雌性的接受度，因为雄性老鼠在暴露于发情期老鼠、母狐狸和母马的粪便气味时会表现出性唤起。通过对来自发情和不发情雌性以及这三种物种雄性的粪便样本进行 GC-MS 分析，鉴定出了 900 多种不同的化合物。在所有发情雌性的粪便中发现了五种浓度较低的羧酸。我们让 12 只经过性训练的雄性老鼠暴露于以雌性发情粪便中发现的相同比例混合的这五种分子的不同稀释液中 30 分钟。将老鼠的行为反应与暴露于水（阴性对照）和发情雌性老鼠的粪便（阳性对照）时的反应进行比较。发现阴茎勃起的频率明显依赖于混合物的稀释度，两个中间稀释度引起的阴茎勃起频率与暴露于发情雌性老鼠粪便时获得的频率没有差异。较高和较低的稀释度不会引起比水更多的阴茎勃起。这些结果支持我们的假设，即一小部分有气味的分子可能表明哺乳动物雌性的性接受度。
