Currently popular dosage schedules of estrogens are not physiologic. Daily large peak fluctuations of circulating estrogen may induce unfamiliar patterns of target cell stimulation which may ultimately be expressed in abnormal cellular activity. For women who require estrogen to control menopausal symptoms, ethinyl estradiol or 17 beta-estradiol is recommended in small daily doses for three weeks (followed by one week off), with the addition of medroxyprogesterone in a small dose in the third week of estrogen treatment.
目前流行的雌激素给药方案不符合生理规律。循环雌激素每日大幅的峰值波动可能会引发不常见的靶细胞刺激模式，最终可能表现为细胞活动异常。对于需要雌激素来控制更年期症状的女性，建议每日小剂量服用炔雌醇或17β - 雌二醇，持续三周（之后停药一周），并在雌激素治疗的第三周添加小剂量的甲羟孕酮。
