Andy J J, Curry C L, Ali N, Mehrotra P P
Am Heart J. 1977 Aug;94(2):175-82. doi: 10.1016/s0002-8703(77)80277-9.
The effects of continuous infusion of dobutamine 5 to 15 microgram/Kg./min. were studied in 17 patients using right heart catheterizations, echocardiography, and/or the Systolic Time Intervals. HR increase was dose-related, but insignificant (p less than 0.05) rate increase was obtained at infusion rates below 15 microgram/Kg.)min. C.O. increased from 2.9 +/- 0.7 to 5.0 +/- 1.2 liters/min. (p less than 0.001), and the stroke volume from 30 +/- 6 to 49 +/- 14 ml./min. (p less than 0.005). The mean BP did not change, P.A.W.P. decreased from 30 +/- 7 to 20 +/- 8 mm. Hg (p less than 0.001) and R.A.P. from 20.0 to 12.0 mm. Hg (p less than 0.005). The P.E.P.I. decreased from 160.93 +/- 54.91 to 133.4 +/- 28.7 msec. (p less than 0.050). Echo-determined mean VCf increased from 0.387 +/- 0.14 to 0.537 +/- 0.13 cm. (p less than 0.010), diastolic diameter did not change significantly, but the end systolic diameter decreased from 6.020 +/- 0.69 to 5.750 +/- 0.70 cm. (p less than 0.025). During a mean infusion period of 75 hours, the only side effects noted were transient nausea and/or vomiting at 15 microgram/Kg./min. dose range in two patients, and multifocal P.V.C.'s following 68 hours of infusion in another patient. It is concluded that in the dose range of 5 to 15 microgram/Kg./min., dobutamine is well tolerated and is a very potent inotropic agent with only minor effects on the heart rate and blood pressure.
对17例患者持续输注5至15微克/千克/分钟的多巴酚丁胺，并使用右心导管检查、超声心动图和/或收缩期时间间期进行了研究。心率增加与剂量相关，但在输注速率低于15微克/千克/分钟时，心率增加不显著（p＜0.05）。心输出量从2.9±0.7升/分钟增加到5.0±1.2升/分钟（p＜0.001），每搏输出量从30±6毫升增加到49±14毫升/分钟（p＜0.005）。平均血压未改变，肺动脉楔压从30±7毫米汞柱降至20±8毫米汞柱（p＜0.001），右心房压从20.0毫米汞柱降至12.0毫米汞柱（p＜0.005）。射血前期时间从160.93±54.91毫秒降至133.4±28.7毫秒（p＜0.050）。超声心动图测定的平均心室周径纤维缩短率从0.387±0.14厘米增加到0.537±0.13厘米（p＜0.010），舒张期直径无显著变化，但收缩末期直径从6.020±0.69厘米降至5.750±0.70厘米（p＜0.025）。在平均输注75小时期间，观察到的唯一副作用是两名患者在15微克/千克/分钟剂量范围出现短暂恶心和/或呕吐，另一名患者在输注68小时后出现多源性室性早搏。结论是，在5至15微克/千克/分钟的剂量范围内，多巴酚丁胺耐受性良好，是一种非常有效的强心剂，对心率和血压影响较小。
