Steinberg J L, Devous M D, Paulman R G
Department of Psychiatry, University of Texas-Houston Medical School, Harris County Psychiatric Center 77225-0249, USA.
Schizophr Res. 1996 May;19(2-3):177-87. doi: 10.1016/0920-9964(96)88525-2.
Dynamic 133Xe single photon emission computed tomography (SPECT) was used to measure regional cerebral blood flow (rCBF) during the Wisconsin Card Sorting test (WCS) and the Number Matching task (NM) in six never-medicated first break schizophrenic and schizophreniform patients, seven chronic schizophrenic patients, and seven normal controls. Because of a difference in mean age between first break patients and normals, we adjusted rCBF data for age effects using ANCOVA. For age-adjusted absolute superior and middle frontal rCBF bilaterally, we found significantly less activation from NM to WCS in first break patients compared to normals. Similarly, for age-adjusted absolute and relative left middle frontal rCBF, we found significantly less activation in chronics compared to normals. Changes in age-adjusted global cerebral blood flow (gCBF) were not statistically significant among the three groups, but were in the same direction as activated absolute frontal rCBF. Because of the small number of subjects in each group, the results of this study should be regarded as preliminary and interpreted cautiously.
在威斯康星卡片分类测试（WCS）和数字匹配任务（NM）过程中，使用动态133Xe单光子发射计算机断层扫描（SPECT）来测量6名未接受过药物治疗的首发精神分裂症和精神分裂症样患者、7名慢性精神分裂症患者以及7名正常对照者的局部脑血流量（rCBF）。由于首发患者与正常人的平均年龄存在差异，我们使用协方差分析（ANCOVA）对rCBF数据的年龄效应进行了校正。对于经年龄校正的双侧绝对额上回和额中回rCBF，我们发现首发患者从NM到WCS的激活程度明显低于正常人。同样，对于经年龄校正的绝对和相对左侧额中回rCBF，我们发现慢性患者的激活程度明显低于正常人。经年龄校正的全脑血流量（gCBF）变化在三组之间无统计学意义，但与激活的绝对额部rCBF方向相同。由于每组受试者数量较少，本研究结果应视为初步结果并谨慎解读。
