Lewis S W, Ford R A, Syed G M, Reveley A M, Toone B K
Department of Psychiatry, Charing Cross and Westminister Medical School, London.
Psychol Med. 1992 Feb;22(1):27-35. doi: 10.1017/s0033291700032694.
Regional cerebral blood flow (rCBF) during a word fluency task was compared in twenty-five male, right-handed, medicated schizophrenic patients and twenty-five age-matched male, right-handed healthy volunteers, using 99mtechnetium-HMPAO multidetector single-photon emission tomography. Increased rCBF in caudate and thalamus was found in patients, probably secondary to neuroleptic medication. Patients showed decreased rCBF in left frontal cortical regions and increased rCBF in left posterior cortical regions, compared to controls. Patterns of left-sided frontal rCBF dominance in controls were reversed in patients, as were normal patterns of right-sided parietal rCBF dominance. Negative symptom score correlated inversely with mesial frontal rCBF, particularly on the left.
使用99m锝-六甲基丙二胺肟多探测器单光子发射断层扫描技术，对25名男性、右利手、正在服药的精神分裂症患者和25名年龄匹配的男性、右利手健康志愿者在词语流畅性任务期间的局部脑血流量（rCBF）进行了比较。发现患者的尾状核和丘脑rCBF增加，这可能继发于抗精神病药物治疗。与对照组相比，患者左侧额叶皮质区域的rCBF降低，左侧后皮质区域的rCBF增加。患者中对照组左侧额叶rCBF优势模式发生了逆转，右侧顶叶rCBF优势的正常模式也是如此。阴性症状评分与内侧额叶rCBF呈负相关，尤其是在左侧。
