Buchsbaum M S, Trestman R L, Hazlett E, Siegel B V, Schaefer C H, Luu-Hsia C, Tang C, Herrera S, Solimando A C, Losonczy M, Serby M, Silverman J, Siever L J
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029-6574, USA.
Schizophr Res. 1997 Oct 17;27(1):21-8. doi: 10.1016/S0920-9964(97)00081-9.
Regional cerebral blood flow (rCBF) was measured by single photon emission computed tomography in 10 patients with schizotypal personality disorder (SPD) and nine age- and sex-matched normal volunteers. Subjects performed both the Wisconsin Card Sort Test (WCST) and a control task, the Symbol Matching Test (SMT). Four-way analyses of variance were performed to assess relative rCBF of the prefrontal cortex and of the medial temporal region. Normal volunteers showed more marked activation in the precentral gyrus, while SPD patients showed greater activation in the middle frontal gyrus. Relative flow in the left prefrontal cortex was correlated with better WCST performance in normal volunteers. SPD patients, however, showed no such correlations in the left prefrontal cortex, but demonstrated correlations of good and bad performance with CBF in the right middle and inferior frontal gyrus, respectively. Thus, at least some SPD patients demonstrate abnormal patterns of prefrontal activation, perhaps as a compensation for dysfunction in other regions.
采用单光子发射计算机断层扫描技术对10例分裂型人格障碍（SPD）患者和9名年龄及性别匹配的正常志愿者进行了局部脑血流量（rCBF）测量。受试者分别完成了威斯康星卡片分类测验（WCST）和一项对照任务——符号匹配测验（SMT）。进行了四因素方差分析以评估前额叶皮质和颞叶内侧区域的相对rCBF。正常志愿者在中央前回表现出更明显的激活，而SPD患者在额中回表现出更大的激活。正常志愿者左侧前额叶皮质的相对血流量与更好的WCST表现相关。然而，SPD患者在左侧前额叶皮质未表现出这种相关性，但分别在右侧额中回和额下回表现出良好和不良表现与CBF的相关性。因此，至少一些SPD患者表现出前额叶激活模式异常，这可能是对其他区域功能障碍的一种补偿。
