果蝇胚胎中的远程抑制。
Long-range repression in the Drosophila embryo.
作者信息
Cai H N, Arnosti D N, Levine M
机构信息
Department of Biology, University of California at San Diego, La Jolla 92093-0347, USA.
出版信息
Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9309-14. doi: 10.1073/pnas.93.18.9309.
Transcriptional repressors can be characterized by their range of action on promoters and enhancers. Short-range repressors interact over distances of 50-150 bp to inhibit, or quench, either upstream activators or the basal transcription complex. In contrast, long-range repressors act over several kilobases to silence basal promoters. We describe recent progress in characterizing the functional properties of one such long-range element in the Drosophila embryo and discuss the contrasting types of gene regulation that are made possible by short- and long-range repressors.
转录抑制因子可根据它们对启动子和增强子的作用范围来进行表征。短程抑制因子在50 - 150碱基对的距离上相互作用，以抑制或淬灭上游激活因子或基础转录复合物。相比之下，长程抑制因子作用于几千个碱基，使基础启动子沉默。我们描述了在表征果蝇胚胎中这样一种长程元件的功能特性方面的最新进展，并讨论了短程和长程抑制因子所实现的不同类型的基因调控。
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