血管活性肠肽对曼氏血吸虫病小鼠肉芽肿性炎症的调节作用

Vasoactive intestinal peptide regulation of granulomatous inflammation in murine Schistosomiasis mansoni.

作者信息

Weinstock J V

机构信息

Department of Internal Medicine, University of Iowa, Iowa City 52242, USA.

出版信息

Adv Neuroimmunol. 1996;6(1):95-105. doi: 10.1016/s0960-5428(96)00009-5.

DOI:10.1016/s0960-5428(96)00009-5

PMID:8790784

Abstract

Schistosomiasis is a parasitic disease in which focal inflammatory responses called granulomas develop in the liver and intestines. The inflammatory cells within these granulomas produce authentic vasoactive intestine peptide (VIP). VIP acts as an immune modulator. In the schistosome granuloma, VIP can suppress T cell proliferation and T lymphocyte IL-2 production. Also, it can enhance IL-5 production from granuloma T cells. The granuloma T cells bear authentic VIP receptors of both the VIPr1 and VIPr2 subclasses. It is probable that the expression of these receptors is subject to immunoregulation, which is the topic of current investigation. Moreover, differences in the structure of VIPr1 and VIPr2 suggest that each may have unique immunoregulatory functions in inflammation.

摘要

血吸虫病是一种寄生虫病，在肝脏和肠道中会形成称为肉芽肿的局部炎症反应。这些肉芽肿内的炎症细胞会产生真正的血管活性肠肽（VIP）。VIP作为一种免疫调节剂。在血吸虫肉芽肿中，VIP可抑制T细胞增殖和T淋巴细胞白细胞介素-2的产生。此外，它还能增强肉芽肿T细胞白细胞介素-5的产生。肉芽肿T细胞带有VIPr1和VIPr2亚类的真正VIP受体。这些受体的表达很可能受到免疫调节，这是当前研究的主题。此外，VIPr1和VIPr2结构上的差异表明，它们各自在炎症中可能具有独特的免疫调节功能。