Camm A J, Fei L
Department of Cardiological Sciences, St George's Hospital Medical School, London, U.K.
Clin Cardiol. 1996 Jun;19(6):503-8. doi: 10.1002/clc.4960190612.
The definition of chronotropic incompetence as inadequate chronotropic response to metabolic demand is, in theory, quite satisfactory. However, the method used in clinical practice for determination of chronotropic incompetence is far from established. The determination of chronotropic incompetence has important diagnostic, therapeutic, and prognostic implications although the exact mechanism underlying chronotropic incompetence is at present unclear. From a pacing viewpoint, chronotropic incompetence is clinically relevant only when there is a functional improvement associated with rate-responsive pacing. Rate-responsive pacing has improved the physiologic approach to artificial pacing.
变时性功能不全的定义为对代谢需求的变时性反应不足，从理论上讲，这一定义相当令人满意。然而，临床实践中用于确定变时性功能不全的方法远未确立。尽管目前变时性功能不全的确切机制尚不清楚，但变时性功能不全的测定具有重要的诊断、治疗和预后意义。从起搏的角度来看，只有当与频率应答性起搏相关的功能得到改善时，变时性功能不全才具有临床相关性。频率应答性起搏改善了人工起搏的生理学方法。
