Hlady V, Buijs J
Vladimir Hlady and Jos Buijs, Center for Biopolymers at Interfaces, Department of Bioengineering, 108 Biomedical Polymer Research Building, Salt Lake City, Utah 84112, USA.
Curr Opin Biotechnol. 1996 Feb 1;7(1):72-7. doi: 10.1016/s0958-1669(96)80098-x.
The research field of protein adsorption on surfaces appears to be as popular as ever. In the past year, several hundred published papers tackled problems ranging from fundamental aspects of protein surface interactions to applied problems of surface blood compatibility and protein surface immobilization. Although some parts of the protein adsorption process, such as kinetics and equilibrium interactions, can be accurately predicted, other aspects, such as the extent and the rate of protein conformational change, are still somewhat uncertain. The whole field is ripe for a comprehensive theory on protein adsorption.
蛋白质在表面吸附的研究领域似乎一如既往地受到欢迎。在过去的一年里，数百篇已发表的论文探讨了从蛋白质表面相互作用的基础方面到表面血液相容性和蛋白质表面固定化等应用问题。尽管蛋白质吸附过程的某些部分，如动力学和平衡相互作用，可以被准确预测，但其他方面，如蛋白质构象变化的程度和速率，仍然有些不确定。整个领域已经具备了一个关于蛋白质吸附的全面理论的条件。
