North R A
Glaxo Institute for Molecular Biology, 14 chemin des Aulx, Plan-les-Quates, 1228 Geneva, Switzerland.
Curr Opin Cell Biol. 1996 Aug;8(4):474-83. doi: 10.1016/s0955-0674(96)80023-8.
The family of epithelial sodium channels and nematode degenerins has expanded recently to include a member found only in brain, and another that functions in molluscs as a ligand-gated channel. A new gene family of mammalian ATP-gated channels has been discovered; one of its seven members plays a role in the lysis of macrophages. The mechanosensitive channel of bacteria has emerged as the simplest form of a channel protein subunit with two hydrophobic domains.
上皮钠通道和线虫退化蛋白家族最近有所扩展，包括一个仅在大脑中发现的成员，以及另一个在软体动物中作为配体门控通道发挥作用的成员。已发现一个新的哺乳动物ATP门控通道基因家族；其七个成员之一在巨噬细胞裂解中起作用。细菌的机械敏感通道已成为具有两个疏水结构域的通道蛋白亚基的最简单形式。
