Ferguson E L
Department of Molecular Genetics, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA.
Curr Opin Genet Dev. 1996 Aug;6(4):424-31. doi: 10.1016/s0959-437x(96)80063-3.
Dorsal-ventral patterning within the ectodermal and mesodermal germ layers of Drosophila and Xenopus embryos is specified by a system of genes that has been conserved over 500 million years of evolution. In both organisms, the activity of the TGF-beta family member DPP/BMP4 is antagonized by SOG/CHORDIN. A second Xenopus gene, noggin, has a similar biological activity to chordin. Analysis of the action of these genes indicate that Spemann's organizer promotes dorsal cell fates in Xenopus by antagonizing a ventralizing signal encoded by the Bmp4 gene.
果蝇和非洲爪蟾胚胎的外胚层和中胚层胚层内的背腹模式是由一个在超过5亿年的进化过程中保守的基因系统所决定的。在这两种生物中，TGF-β家族成员DPP/BMP4的活性受到SOG/CHORDIN的拮抗。非洲爪蟾的另一个基因noggin具有与chordin相似的生物学活性。对这些基因作用的分析表明，施佩曼组织者通过拮抗由Bmp4基因编码的腹侧化信号来促进非洲爪蟾的背侧细胞命运。
