Hogan B L
Howard Hughes Medical Institute Research Laboratories, Vanderbilt University School of Medicine, C-2310 Medical Center North, Nashville, Tennessee 37232-2174, USA.
Curr Opin Genet Dev. 1996 Aug;6(4):432-8. doi: 10.1016/s0959-437x(96)80064-5.
The bone morphogenetic proteins (BMPs) constitute a large family of cytokines related to members of the transforming growth factor-beta superfamily. Recent evidence, in particular from gene targeting experiments in the mouse, indicates that BMPs are required for mesoderm formation and for the development and patterning of many different organ systems. Significant progress has also been made in understanding the role of BMPs in gastrulation and neurulation in Xenopus and in identifying genes regulating BMP expression and components of the downstream signaling pathways. Extracellular modifiers of BMP activity may constitute an opposing morphogenetic system.
骨形态发生蛋白（BMPs）构成了一个与转化生长因子-β超家族成员相关的细胞因子大家族。最近的证据，特别是来自小鼠基因靶向实验的证据表明，BMPs对于中胚层形成以及许多不同器官系统的发育和模式形成是必需的。在理解BMPs在非洲爪蟾原肠胚形成和神经胚形成中的作用以及鉴定调节BMP表达的基因和下游信号通路的组成部分方面也取得了重大进展。BMP活性的细胞外调节剂可能构成一个相反的形态发生系统。
