Mehta R C, Pike G B, Enzmann D R
Department of Radiology, Stanford University School of Medicine, CA 94305, USA.
AJNR Am J Neuroradiol. 1996 Jun-Jul;17(6):1051-5.
To define the percentage of magnetization transfer of multiple sclerosis (MS) plaques, ischemic white matter lesions, and vasogenic edema to determine whether this measurement can help differentiate these entities.
Findings were compared in 25 patients with proved MS, 20 patients with white matter ischemic lesions, and 72 patients with white matter edema (caused by tumors, infections, or acute/subacute infarctions) in the periventricular system, centrum semiovale, and subcortical white matter. Magnetization transfer was performed using an on-resonance binomial pulse. The percentage of magnetization transfer of the normal white matter was also calculated.
Magnetization transfer was significantly higher in white matter ischemic lesions (range, 31% to 38%; mean, 34% +/- 0.6%) than in demyelinating plaques of MS (range, 19% to 28%; mean, 22.5% +/- 1%) and in edema (range, 29% to 37%; mean, 30.2% +/- 0.4%). No statistical difference in percentage of magnetization transfer was found among lesions in the periventricular system (34% +/- 0.6%), centrum semiovale (35% +/- 0.5%), or subcortical white matter (33% +/- 0.6%), or in vasogenic edema associated with tumors, infections, or infarction.
Differences in magnetization transfer suggest less change of demyelination in white matter ischemic lesions than in MS plaques and are significantly different in this respect from similar MS plaques. Magnetization transfer of edema was less than that of normal white matter or fell between ischemic abnormalities and MS plaques. Percentages of magnetization transfer below the mid-20% range is highly suggestive of demyelination. Vasogenic edema, our surrogate for increased water content of white matter, caused a decrease in the percentage of magnetization transfer.
确定多发性硬化（MS）斑块、缺血性白质病变和血管源性水肿的磁化传递百分比，以判断该测量方法是否有助于鉴别这些病变。
对25例确诊为MS的患者、20例有白质缺血性病变的患者以及72例在脑室周围系统、半卵圆中心和皮质下白质有白质水肿（由肿瘤、感染或急性/亚急性梗死引起）的患者的检查结果进行比较。使用共振二项式脉冲进行磁化传递。还计算了正常白质的磁化传递百分比。
白质缺血性病变的磁化传递明显高于MS脱髓鞘斑块（范围为19%至28%；平均为22.5%±1%）和水肿（范围为29%至37%；平均为30.2%±0.4%），范围为31%至38%；平均为34%±0.6%）。在脑室周围系统（34%±0.6%）、半卵圆中心（35%±0.5%）或皮质下白质（33%±0.6%）的病变之间，以及与肿瘤、感染或梗死相关的血管源性水肿之间，磁化传递百分比没有统计学差异。
磁化传递的差异表明，白质缺血性病变中的脱髓鞘变化比MS斑块中的少，在这方面与类似的MS斑块有显著差异。水肿的磁化传递低于正常白质或介于缺血性异常和MS斑块之间。磁化传递百分比低于20%中期范围高度提示脱髓鞘。血管源性水肿，即我们对白质含水量增加的替代指标，导致磁化传递百分比降低。
