Filippi Massimo, Rocca Maria A
Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Hospital San Raffaele, Milan, Italy.
Neurotherapeutics. 2007 Jul;4(3):401-13. doi: 10.1016/j.nurt.2007.03.002.
Magnetic resonance imaging is highly sensitive in revealing CNS abnormalities associated with several neurological conditions, but lacks specificity for their pathological substrates. In addition, MRI does not allow evaluation of the presence and extent of damage in regions that appear normal on conventional MRI sequences and that postmortem studies have shown to be affected by pathology. Quantitative MR-based techniques with increased pathological specificity to the heterogeneous substrates of CNS pathology have the potential to overcome such limitations. Among these techniques, one of the most extensively used for the assessment of CNS disorders is magnetization transfer MRI (MT-MRI). The application of this technique for the assessment of damage in macroscopic lesions, in normal-appearing white and gray matter, and in the spinal cord and optic nerve of patients with several neurological conditions is providing important in vivo information-dramatically improving our understanding of the factors associated with the appearance of clinical symptoms and the accumulation of irreversible disability. MT-MRI also has the potential to contribute to the diagnostic evaluation of several neurological conditions and to improve our ability to monitor treatment efficacy in experimental trials.
磁共振成像在揭示与多种神经系统疾病相关的中枢神经系统异常方面具有高度敏感性，但对其病理基质缺乏特异性。此外，MRI无法评估在传统MRI序列上看似正常且尸检研究已表明受病理影响的区域中损伤的存在和程度。对中枢神经系统病理异质基质具有更高病理特异性的基于磁共振的定量技术有可能克服这些局限性。在这些技术中，用于评估中枢神经系统疾病最广泛使用的技术之一是磁化传递MRI（MT-MRI）。该技术在评估多种神经系统疾病患者的宏观病变、外观正常的白质和灰质以及脊髓和视神经中的损伤时，提供了重要的体内信息，极大地增进了我们对与临床症状出现和不可逆残疾积累相关因素的理解。MT-MRI还有助于对多种神经系统疾病进行诊断评估，并提高我们在实验性试验中监测治疗效果的能力。
