Tomiak M M, Rosenblum J D, Prager J M, Metz C E
University of Chicago Hospitals, Department of Radiology, IL 60637.
AJNR Am J Neuroradiol. 1994 Sep;15(8):1569-74.
To determine whether magnetization transfer contrast can differentiate acute from chronic lesions in multiple sclerosis.
Thirteen patients with multiple sclerosis and eight healthy patients were studied with MR using a 0.1-T system. Relatively T2-weighted spin-echo images were obtained without and with magnetization transfer contrast. The magnetization transfer effect of multiple sclerosis lesions was calculated and compared with the ages of the lesions. The magnetization transfer effect of normal-appearing white matter in patients with multiple sclerosis was calculated and compared with the magnetization transfer effect of white matter in healthy volunteers. Statistical analysis was performed.
White matter in the healthy volunteers had values from 0.40 to 0.45. Normal-appearing white matter in the patients with multiple sclerosis had magnetization transfer effect values ranging from 0.41 to 0.45. Multiple sclerosis plaques of less than 1 year's duration had magnetization transfer effect values ranging from 0.05 to 0.26; older plaques had values from 0.25 to 0.41. The difference in the distributions of these values for acute and chronic multiple sclerosis plaques is statistically significant.
Current imaging modalities do not differentiate acute multiple sclerosis lesions from chronic ones. Our data on magnetization transfer show a statistically significant difference in magnetization transfer effect values between lesions of less than 1 year's duration and older lesions. The different values may correspond to the histologic changes of multiple sclerosis plaques over time. Magnetization transfer may be a reliable method for determining the age of multiple sclerosis lesions.
确定磁化传递对比是否能区分多发性硬化症的急性病变与慢性病变。
使用0.1-T系统对13例多发性硬化症患者和8名健康受试者进行磁共振成像研究。在有无磁化传递对比的情况下获取相对T2加权自旋回波图像。计算多发性硬化症病变的磁化传递效应，并与病变的年龄进行比较。计算多发性硬化症患者正常外观白质的磁化传递效应，并与健康志愿者白质的磁化传递效应进行比较。进行统计学分析。
健康志愿者白质的磁化传递效应值为0.40至0.45。多发性硬化症患者正常外观白质的磁化传递效应值为0.41至0.45。病程小于1年的多发性硬化症斑块的磁化传递效应值为0.05至0.26；病程较长的斑块的磁化传递效应值为0.25至0.41。急性和慢性多发性硬化症斑块这些值的分布差异具有统计学意义。
目前的成像方式无法区分急性和慢性多发性硬化症病变。我们关于磁化传递的数据显示，病程小于1年的病变与病程较长的病变在磁化传递效应值上存在统计学上的显著差异。这些不同的值可能与多发性硬化症斑块随时间的组织学变化相对应。磁化传递可能是确定多发性硬化症病变年龄的可靠方法。
