Rutland A, Ballard C
Am J Obstet Gynecol. 1977 Jul 1;128(5):503-6. doi: 10.1016/0002-9378(77)90032-1.
Vaginal suppositories containing 20 mg. of prostaglandin E2 (PGE2) were given to 50 patients with a diagnosis of either missed abortion or fetal death. A total of 94 percent of the patients (47/50) expelled products of conception, and 84 percent of these expulsions (42/50) were complete. The mean time to expulsion of the fetus was 11.3 hours with a mean dose of 3.6 suppositiries. A total 60 per cent of the patients experienced vomiting, diarrhea, and pyrexia. Four patients had a blood loss in excess of 500 ml., and two of these patients required blood transfusion. Vaginal administration of PGE2 suppositories appeared to be a rapid, safe, and reliable means of managing missed abortion and intrauterine fetal death.
给50例诊断为稽留流产或死胎的患者使用含20毫克前列腺素E2（PGE2）的阴道栓剂。共有94%的患者（47/50）排出妊娠产物，其中84%（42/50）的排出是完全的。排出胎儿的平均时间为11.3小时，平均剂量为3.6枚栓剂。共有60%的患者出现呕吐、腹泻和发热。4例患者失血超过500毫升，其中2例患者需要输血。阴道给药PGE2栓剂似乎是处理稽留流产和宫内死胎的一种快速、安全且可靠的方法。
