Lauersen N H, Wilson K H
Am J Obstet Gynecol. 1977 Mar 15;127(6):609-11. doi: 10.1016/0002-9378(77)90358-1.
Labor was successfully induced in 20 patients with a diagnosis of missed abortion or intrauterine fetal death (IUFD) by intravaginal administration of prostaglandin E2 suppositories. Fifteen patients delivered with the prostaglandin alone while a concomitant oxytocin infusion was employed to augment contractions in the other five patients. The mean induction-delivery time was 9.80 hours; nulliparous patients delivered in a mean time if 7.78 hours, parous patients in a mean time of 12.29 hours. The uterus appeared to be sensitive to the PGE2 stimulation in all patients and all were delivered completely without the need for surgical intervention. Fifty per cent of patients were delivered within 8 hours and 80 per cent by 12 hours. The side effects associated with prostaglandin administration--vomiting, diarrhea, and temperature elevation--were well tolerated and therapy did not have to be terminated in any patient. The administration of PGE2 vaginal suppositories offers an effective and safe technique for the induction of labor in patients with IUFD. Labor can be induced with PGE2 suppositories as soon as the diagnosis of IUFD is confirmed, which eliminates the need for waiting until spontaneous labor occurs.
通过阴道内给予前列腺素E2栓剂，成功诱导了20例诊断为稽留流产或死胎（IUFD）的患者分娩。15例患者仅使用前列腺素就分娩了，而另外5例患者则同时使用催产素输注以增强宫缩。平均引产至分娩时间为9.80小时；初产妇平均分娩时间为7.78小时，经产妇平均分娩时间为12.29小时。所有患者的子宫似乎对PGE2刺激敏感，所有患者均完全分娩，无需手术干预。50%的患者在8小时内分娩，80%的患者在12小时内分娩。与前列腺素给药相关的副作用——呕吐、腹泻和体温升高——耐受性良好，没有任何患者需要终止治疗。PGE2阴道栓剂给药为IUFD患者引产提供了一种有效且安全的技术。一旦确诊IUFD，即可使用PGE2栓剂引产，无需等待自然分娩。
