Morita T, Saeki H, Imai S, Ishii T
Department of Parasitology, Nippon Veterinary and Animal Science University, Tokyo, Japan.
Vet Parasitol. 1996 May;63(1-2):1-7. doi: 10.1016/0304-4017(95)00892-6.
We have already reported that anti-erythrocyte antibody induced by Babesia gibsoni infection (aEAb) showed higher reactivity against aged and/or oxidized erythrocytes than intact one in vitro (Morita et al., 1995). To clarify the meaning of such a binding character of aEAb in vivo, changes in erythrocyte oxidation were observed in artificially infected dogs. The ratio of methemoglobin concentration against total hemoglobin concentration (metHb%) as the indicator of erythrocyte oxidation was increased by the artificial infection in the intact dogs, suggesting that aEAb played a more important role in erythrocyte destruction in infected dogs. Though parasitemia approximately three times higher was observed in splenectomized dogs than that in intact dogs, metHb% did not increase in the splenectomized dogs. This suggests that the spleen plays a very important role in erythrocyte oxidation in dogs infected with B. gibsoni.
我们已经报道过，吉氏巴贝斯虫感染诱导产生的抗红细胞抗体（aEAb）在体外对衰老和/或氧化红细胞的反应性高于完整红细胞（森田等人，1995年）。为了阐明aEAb在体内这种结合特性的意义，我们观察了人工感染犬的红细胞氧化变化。完整犬经人工感染后，作为红细胞氧化指标的高铁血红蛋白浓度与总血红蛋白浓度之比（高铁血红蛋白%）升高，这表明aEAb在感染犬的红细胞破坏中起更重要的作用。虽然脾切除犬的虫血症比完整犬高约三倍，但脾切除犬的高铁血红蛋白%并未升高。这表明脾脏在感染吉氏巴贝斯虫的犬的红细胞氧化中起非常重要的作用。
