Field L L, Tobias R, Magnus T
Department of Medical Genetics, University of Calgary, Alberta, Canada.
Nat Genet. 1994 Oct;8(2):189-94. doi: 10.1038/ng1094-189.
To identify new loci predisposing to insulin-dependent diabetes mellitus (IDDM), we have investigated 250 families with more than one diabetic child. Affected sibling pair linkage analysis revealed strong evidence for an IDDM susceptibility locus near D15S107 on chromosome 15q26 (P = 0.0010) termed IDDM3. Families less predisposed through genes in the HLA region provided most of the evidence for linkage. In these families, discordant sibling pairs also showed linkage (P = 0.0052), and sibling pair disease concordance or discordance was strongly related to the proportion of genes the pair shared at D15S107 (P = 0.0003). Our study also revealed evidence for an IDDM locus on chromosome 11q13 (IDDM4) using affected siblings (P = 0.0043), but no evidence using discordant siblings.
为了确定导致胰岛素依赖型糖尿病（IDDM）的新基因座，我们研究了250个有不止一个患糖尿病孩子的家庭。受累同胞对连锁分析显示，在15号染色体15q26上靠近D15S107处存在一个IDDM易感基因座，证据确凿（P = 0.0010），该基因座被命名为IDDM3。通过HLA区域基因遗传倾向较低的家庭为连锁提供了大部分证据。在这些家庭中，不一致的同胞对也显示出连锁（P = 0.0052），并且同胞对疾病的一致性或不一致性与该对在D15S107共享的基因比例密切相关（P = 0.0003）。我们的研究还显示，使用受累同胞时，在11号染色体11q13上存在一个IDDM基因座（IDDM4）的证据（P = 0.0043），但使用不一致同胞时没有证据。
