Leo R J, Kreeger J L, Kim K Y
Department of Psychiatry, School of Medicine and Biomedical Sciences, State University of New York (SUNY) at Buffalo 14215, USA.
Ann Pharmacother. 1996 Jun;30(6):603-5. doi: 10.1177/106002809603000606.
To report a case of symptomatic cardiomyopathy induced during treatment with clozapine, an antipsychotic of the dibenzodiazepine class.
A patient with a long psychiatric history significant for schizophrenia and no prior cardiac history developed dyspnea, malaise, and edema with a low ventricular ejection fraction during clozapine therapy.
The literature concerning cardiorespiratory complications with clozapine therapy is reviewed.
Cardiorespiratory complications associated with clozapine use are rare. Caution may be warranted in patients treated with other medications, such as benzodiazepines, and in patients with underlying cardiac disease.
报告1例使用二苯并二氮䓬类抗精神病药物氯氮平治疗期间诱发的有症状性心肌病病例。
1例有长期精神病史且诊断为精神分裂症、既往无心脏病史的患者，在氯氮平治疗期间出现呼吸困难、不适及水肿，心室射血分数降低。
对有关氯氮平治疗引起心肺并发症的文献进行了综述。
与使用氯氮平相关的心肺并发症很罕见。对于接受其他药物（如苯二氮䓬类药物）治疗的患者以及有潜在心脏疾病的患者，可能需要谨慎用药。
