Thullier F, Lalonde R, Mahler P, Joyal C C, Lestienne F
Université de Nancy 1, Laboratoire de Biologie et Physiologie du Comportement, URA CNRS 1293, Vandoeuvre-les-Nancy, France. thullier@scbiol. u-nancy.fr
Arch Physiol Biochem. 1996;104(3):307-12. doi: 10.1076/apab.104.3.307.12895.
Rats with small electrolytic lesions of the dorsal striatum were evaluated in acquisition of spatial learning, sensorimotor learning, and a straight runway food approach response and its extinction. No differences were detected between rats with dorsal striatal lesions and sham-operated controls during acquisition of hidden and visible trials in the Morris water maze. Neither was an intergroup difference observed during acquisition of the rotorod test of motor coordination. Lesioned rats were not impaired in running for a food reward, but their running latencies on day 2 of extinction were lower than those of controls, an indication of perseveration. These results indicate that perseverative responding may occur in dorsal striatal lesioned rats in the absence of spatial or sensorimotor defects.
对背侧纹状体有小电解损伤的大鼠进行了空间学习、感觉运动学习、直线跑道食物趋近反应及其消退方面的习得评估。在莫里斯水迷宫的隐藏和可见试验习得过程中，背侧纹状体损伤大鼠与假手术对照组之间未检测到差异。在运动协调的转棒试验习得过程中也未观察到组间差异。损伤大鼠在为获取食物奖励而奔跑时未受损，但它们在消退第2天的奔跑潜伏期低于对照组，这表明存在持续性。这些结果表明，在没有空间或感觉运动缺陷的情况下，背侧纹状体损伤大鼠可能会出现持续性反应。
