Jeljeli M, Strazielle C, Caston J, Lalonde R
Faculté des Sciences (UPRES PSY CO-EA 1780), Université de Rouen, 76821 Cedex, Mont-Saint-Aignan, France.
Neurosci Res. 2003 Nov;47(3):309-16. doi: 10.1016/s0168-0102(03)00224-4.
The ventrolateral-ventromedial (VL-VM) nuclei are classified as a motor area of the thalamus on the basis of predominant input from the cerebellum and the basal ganglia and output to the motor cortex. The sensitivity to electrolytic lesions of the VL-VM thalamic nuclei in rats was evaluated for tests requiring balance and equilibrium. VL-VM lesions impaired acquisition of the rotorod test but had no effect on stationary beam and hole-board tests. A selective impairment was also observed in the Morris water maze, as VL-VM thalamic lesions slowed down acquisition of the hidden platform but not the visible platform condition. These results support the hypothesis that thalamic motor nuclei participate in the acquisition of sensorimotor and spatial learning.
腹外侧-腹内侧（VL-VM）核基于来自小脑和基底神经节的主要输入以及向运动皮层的输出，被归类为丘脑的一个运动区域。针对需要平衡和平衡能力的测试，评估了大鼠VL-VM丘脑核电解损伤的敏感性。VL-VM损伤损害了转棒试验的习得，但对静止横梁和洞板试验没有影响。在莫里斯水迷宫中也观察到了选择性损伤，因为VL-VM丘脑损伤减缓了隐藏平台条件下的习得，但对可见平台条件没有影响。这些结果支持了丘脑运动核参与感觉运动和空间学习习得的假说。
