de Mello C F, Begnini J, Jiménez-Bernal R E, Rubin M A, de Bastiani J, da Costa E, Wajner M
Departamento de Química, Universidade Federal de Santa Maria, Brazil.
Brain Res. 1996 May 20;721(1-2):120-5. doi: 10.1016/0006-8993(96)00117-5.
The effect of intrastriatal administration of methylmalonic acid (MMA), a metabolite that accumulates in methylmalonic aciduria, on behavior of adult male Wistar rats was investigated. After cannula placing, rats received unilateral intrastriatal injections of MMA (buffered to pH 7.4 with NaOH) or NaCl. MMA induced rotational behavior toward the contralateral side of injection and clonic convulsions in a dose-dependent manner. Rotational behavior and convulsions were prevented by intrastriatal preadministration of MK-801 and attenuated by preadministration of succinate. This study provides evidence for a participation of NMDA receptors in the MMA-induced behavioral alterations, where succinate dehydrogenase inhibition seems to have a pivotal role.
研究了甲基丙二酸（MMA，一种在甲基丙二酸尿症中积累的代谢产物）纹状体内给药对成年雄性Wistar大鼠行为的影响。插管后，大鼠接受纹状体内单侧注射MMA（用NaOH缓冲至pH 7.4）或NaCl。MMA以剂量依赖性方式诱导向注射对侧的旋转行为和阵挛性惊厥。纹状体内预先给予MK-801可预防旋转行为和惊厥，预先给予琥珀酸可减轻旋转行为和惊厥。本研究为NMDA受体参与MMA诱导的行为改变提供了证据，其中琥珀酸脱氢酶抑制似乎起关键作用。
