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线粒体功能障碍和氧化应激中甲基丙二酸的调节和特征：从基础研究到临床实践。

The Regulation and Characterization of Mitochondrial-Derived Methylmalonic Acid in Mitochondrial Dysfunction and Oxidative Stress: From Basic Research to Clinical Practice.

机构信息

Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.

The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 246 Xuefu Road, Nangang District, 150086 Harbin, China.

出版信息

Oxid Med Cell Longev. 2022 May 24;2022:7043883. doi: 10.1155/2022/7043883. eCollection 2022.

DOI:10.1155/2022/7043883
PMID:35656023
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9155905/
Abstract

Methylmalonic acid (MMA) can act as a diagnosis of hereditary methylmalonic acidemia and assess the status of vitamin B12. Moreover, as a new potential biomarker, it has been widely reported to be associated with the progression and prognosis of chronic diseases such as cardiovascular events, renal insufficiency, cognitive impairment, and cancer. MMA accumulation may cause oxidative stress and impair mitochondrial function, disrupt cellular energy metabolism, and trigger cell death. This review primarily focuses on the mechanisms and epidemiology or progression in the clinical study on MMA.

摘要

甲基丙二酸（MMA）可作为遗传性甲基丙二酸血症的诊断指标，并评估维生素 B12 的状况。此外，作为一种新的潜在生物标志物，它已被广泛报道与心血管事件、肾功能不全、认知障碍和癌症等慢性疾病的进展和预后有关。MMA 的积累可能会导致氧化应激和损害线粒体功能，破坏细胞能量代谢，并引发细胞死亡。本综述主要关注 MMA 在临床研究中的机制和流行病学或进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b13c/9155905/3272a4786fdb/OMCL2022-7043883.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b13c/9155905/3272a4786fdb/OMCL2022-7043883.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b13c/9155905/3272a4786fdb/OMCL2022-7043883.001.jpg

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