Franceschi S, Schinella D, Bidoli E, Dal Maso L, La Vecchia C, Parazzini F, Zecchin R
Servizio di Epidemiologia, Centro di Riferimento Oncologico, Aviano, Italy.
Epidemiology. 1996 Jul;7(4):411-4. doi: 10.1097/00001648-199607000-00012.
We studied the determinants of low bone mineral density, using data from a population-based screening program of osteoporosis carried out among 1,373 women (age 40-64 years) in the province of Pordenone, Italy, by means of dual photon absorptiometry of the lumbar spine. Menopause had a major effect on bone mineral density. Age had little influence before menopause. In multivariate linear regression analyses, weight was the strongest predictor of bone mineral density in pre- as well as postmenopausal women. After the inclusion in a single model of a term for current weight, weight at ages 12 and 30 years explained some additional variance, whereas high waist-to-hip ratio (an indicator of central adiposity) had no influence. Smoking 15 or more cigarettes per day entailed a small increased risk of osteoporosis, but this effect, independent of weight, appeared to be restricted to premenopausal women. No food or micronutrient that we examined was predictive of bone mineral density, nor was coffee or alcoholic beverage intake.
我们利用意大利波代诺内省对1373名年龄在40至64岁之间的女性开展的一项基于人群的骨质疏松症筛查项目的数据，通过腰椎双能光子吸收测定法，研究了低骨矿物质密度的决定因素。绝经对骨矿物质密度有重大影响。绝经前年龄影响较小。在多变量线性回归分析中，体重是绝经前和绝经后女性骨矿物质密度的最强预测因素。在将当前体重这一变量纳入单一模型后，12岁和30岁时的体重解释了一些额外的差异，而高腰臀比（中心性肥胖的一个指标）则没有影响。每天吸烟15支或更多会使患骨质疏松症的风险略有增加，但这种与体重无关的影响似乎仅限于绝经前女性。我们所研究的任何食物或微量营养素都不能预测骨矿物质密度，咖啡或酒精饮料的摄入量也不能。
