Feldman H A
Am J Physiol. 1977 Jul;233(1):R1-7. doi: 10.1152/ajpregu.1977.233.1.R1.
A numerical method is presented for obtaining the exchange rates of a metabolic compartmental system, working directly from the time course of tracer activity and excretion after bolus injection. The conventional mathematical formulation of this problem, in terms of sums of exponential functions, is bypassed, enabling implementation of the method in a short computer program. An important by-product of the method is a set of variance-covariance estimates for the fitted parameters. The method is tested on "classic" data, both simulated and real. Its capabilities and limitations are demonstrated, and the strategy of its effective application is discussed.
本文提出了一种数值方法，可直接根据团注注射后示踪剂活性和排泄的时间进程来获取代谢隔室系统的交换率。该问题的传统数学公式（以指数函数之和表示）被绕过，从而能够在一个简短的计算机程序中实现该方法。该方法的一个重要副产品是一组拟合参数的方差 - 协方差估计值。该方法在模拟和真实的“经典”数据上进行了测试。展示了其能力和局限性，并讨论了有效应用该方法的策略。
