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A short parameter-fitting routine for compartmental models.

作者信息

Feldman H A

出版信息

Comput Programs Biomed. 1977 Sep;7(3):135-44. doi: 10.1016/0010-468x(77)90022-8.

DOI:10.1016/0010-468x(77)90022-8
PMID:891154
Abstract

We have developed a program of 298 FORTRAN statements which obtains the inter-pool exchange rates and other parameters of a compartmental system, working directly from the time course of tracer activity after a bolus injection. The fitting problem - data and model - is specified by the user in a natural syntactic style. The program calculates least-squares estimates, confidence limits and intercorrelation estimates for the fitted parameters. Its small size and conceptual simplicity make the program a powerful practical tool for analyzing tracer studies.

摘要

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