Martel S, Carré P C, Carrera G, Pipy B, Léophonte P J
Service de Pneumologie et Allergologie et INSERM CIF 91-07, CHU Rangueil, Toulouse, France.
Eur Respir J. 1996 May;9(5):1087-9. doi: 10.1183/09031936.96.09051087.
Recurrence of sarcoidosis in lung allografts is an interesting model to study the pathogenesis of this disease. We report a case of sarcoidosis recurrence in a single lung allograft recipient 2 years after transplantation. The expression of tumour necrosis factor-alpha (TNF-alpha) gene by alveolar macrophages was monitored. The TNF-alpha gene was not expressed at the time of recurrence of sarcoidosis, but only later when prominent granulomas were observed.
肺移植中结节病的复发是研究该疾病发病机制的一个有趣模型。我们报告了1例单肺移植受者在移植2年后出现结节病复发的病例。监测了肺泡巨噬细胞中肿瘤坏死因子-α（TNF-α）基因的表达。在结节病复发时TNF-α基因未表达，而是在后来观察到明显肉芽肿时才表达。
