Davila G W, Shroyer K R
Colorado Gynecology and Continence Center, Denver, CO 80218, USA.
Gynecol Obstet Invest. 1996;41(4):275-7. doi: 10.1159/000292283.
Chemosurgical treatment of vaginal/cervical human papillomavirus (HPV) infection with 5-fluorouracil (5-FU) is limited by vulvar pain and dysuria resultant from leakage and vulvar/urethral tissue reaction to the 5-FU. Women with cervical HPV DNA identified by in situ hybridization on colposcopically directed biopsy were treated with topically applied 5% 5-FU cream. A fitted cervical cap was used to restrict exposure to 5-FU. Repeat biopsies and in situ hybridization at least 6 weeks after application failed to detect HPV DNA in 6 of 7 patients. In 1 case, 5-FU treatment was associated with a decreased intensity of detectable HPV DNA. No episodes of vulvar pain or dysuria occurred. 5-FU can be used in the treatment of cervical HPV with minimal side effects when applied utilizing a cervical cap.
5-氟尿嘧啶（5-FU）对阴道/宫颈人乳头瘤病毒（HPV）感染进行化学外科治疗时，会受到外阴疼痛和排尿困难的限制，这些症状是由5-FU渗漏以及外阴/尿道组织反应引起的。通过阴道镜引导活检的原位杂交鉴定出宫颈HPV DNA的女性，接受了局部应用5% 5-FU乳膏的治疗。使用合适的宫颈帽来限制5-FU的暴露。用药后至少6周进行重复活检和原位杂交，7例患者中有6例未检测到HPV DNA。在1例患者中，5-FU治疗使可检测到的HPV DNA强度降低。未发生外阴疼痛或排尿困难的情况。当使用宫颈帽应用5-FU时，可用于治疗宫颈HPV，且副作用最小。
