Birley H D, Luzzi G A, Walker M M, Ryait B, Taylor-Robinson D, Renton A M
Department of Genitourinary Medicine and Communicable Disease, St Mary's Hospital Medical School, London, UK.
Int J STD AIDS. 1994 Mar-Apr;5(2):139-41. doi: 10.1177/095646249400500213.
The features and clinical course of chronic balanitis in 5 patients are presented. In each case, histological examination of a cutaneous biopsy sample showed pronounced features of human papillomavirus (HPV) infection. In addition, HPV DNA was demonstrated in each biopsy specimen by a polymerase chain reaction and was found to be type 6 by Southern blot hybridization in 4 of the cases. Although the association of histological features of HPV infection with balanitis does not prove that HPV is causal, the failure to find other causes, the prolonged and distressing symptoms, and the ineffectiveness of topical steroids in improving symptoms, all suggest the importance of HPV infection. While effective treatment needs to be sought and developed, the response of one patient to oral isotretinoin suggests that this agent may be appropriate for a larger trial.
本文介绍了5例慢性龟头炎患者的特征及临床病程。在每例患者中，皮肤活检样本的组织学检查均显示出明显的人乳头瘤病毒（HPV）感染特征。此外，通过聚合酶链反应在每个活检标本中均检测到HPV DNA，其中4例经Southern印迹杂交检测为6型。虽然HPV感染的组织学特征与龟头炎之间的关联并不能证明HPV具有因果关系，但未发现其他病因、症状持续时间长且令人痛苦，以及局部使用类固醇对改善症状无效，均提示HPV感染的重要性。虽然需要寻找和开发有效的治疗方法，但1例患者对口服异维A酸的反应表明，该药物可能适合进行更大规模的试验。
